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Upstream Bio

Upstream Bio (NASDAQ: UPB) insider transactions

In the twelve months to 10 November 2026, executives and directors of Upstream Bio reported 15 open-market sales of 15,061 shares ($104,796) and 0 open-market purchases, by 5 people, according to the Form 4 filings they submitted to the SEC.

Latest transactions

The 20 most recent transactions in Upstream Bio shares reported on Form 4
DateInsiderRoleTransactionSharesPriceHeld afterFiling
16 September 2026Ambrose AllisonGeneral CounselOpen-market sale−485$5.4915,563Form 4
16 September 2026Gray MichaelCFO and COOOpen-market sale−853$5.4927,942Form 4
16 September 2026Houghton AdamChief Business OfficerOpen-market sale−700$5.4922,901Form 4
16 September 2026Sutherland Everett RandChief Executive OfficerOpen-market sale−2,095$5.4968,717Form 4
16 September 2026Deykin AaronChief Medical OfficerOpen-market sale−895$5.4932,302Form 4
16 June 2026Ambrose AllisonGeneral CounselOpen-market sale−477$6.1016,048Form 4
16 June 2026Deykin AaronChief Medical OfficerOpen-market sale−895$6.1033,197Form 4
16 June 2026Houghton AdamChief Business OfficerOpen-market sale−700$6.1023,601Form 4
16 June 2026Sutherland Everett RandChief Executive OfficerOpen-market sale−2,095$6.1070,812Form 4
16 June 2026Gray MichaelCFO and COOOpen-market sale−853$6.1028,795Form 4
16 March 2026Houghton AdamChief Business OfficerOpen-market sale−699$9.2924,301Form 4
16 March 2026Ambrose AllisonGeneral CounselOpen-market sale−475$9.2916,525Form 4
16 March 2026Sutherland Everett RandChief Executive OfficerOpen-market sale−2,093$9.2972,907Form 4
16 March 2026Deykin AaronChief Medical OfficerOpen-market sale−894$9.2932,687Form 4
16 March 2026Gray MichaelCFO and COOOpen-market sale−852$9.2929,648Form 4
2 January 2026Sutherland Everett RandChief Executive OfficerGrant or award+75,000—75,000Form 4
2 January 2026Houghton AdamChief Business OfficerGrant or award+25,000—25,000Form 4
2 January 2026Ambrose AllisonGeneral CounselGrant or award+17,000—17,000Form 4
2 January 2026Deykin AaronChief Medical OfficerGrant or award+32,000—33,581Form 4
2 January 2026Gray MichaelCFO and COOGrant or award+30,500—30,500Form 4

Names appear as in the filing, surname first. A dash in the price column means the filing reports none, as in grants and gifts.

How to read the table

Only open-market purchases and sales are trades the insider chose to make at the market price, and they are the ones counted in the summary above. Grants, option exercises and shares withheld for tax come from pay plans. A sale marked as a 10b5-1 plan was scheduled in advance under a written plan.

Where each row comes from

From the Form 4 that each executive, director or large shareholder must file with the SEC within two business days of a transaction, read up to 10 November 2026. Each row links to its filing on EDGAR. Only transactions in shares are listed, not derivatives, and amended filings are left out. The accounts of the company are on the Upstream Bio page; the method, in data sources.

Information prepared from the Form 4 filings submitted to the SEC, for information purposes only. It is not financial advice or a recommendation to buy or sell. Updated on 12 November 2026.